PVA

Introduction to PVA

• PVA is one of the most famous water-soluble synthetic polymers.

• PVA has hydrophilic groups and hydrophobic groups in the molecule.

• PVA film has high gas barrier ability, so PVA can be used for oxygen barrier, odor masking and moisture barrier coating.

• PVA has good adhesive ability and can be used for wet granulation as binder.

• PVA can be used for solid dispersion (HME).

Structure of PVA

PVA Specification

Specification of PE-05JPS & PE-05JP

• The difference between PE-05JPS and PE-05JP is only particle size.

• Our PVA meet the requirements of all three major compendiums.

• Drug Master File No. 30236

• GAB^* certification No. GAB0180031

• CDE Registration No. F20190000286 (Oral administration)

* GAB: GMP Auditing Board for Pharmaceutical Excipients (Japan)

Applications

Moisture Barrier Coating

• PVA has good gas barrier ability and can achieve moisture barrier coating for tablets.

• Adding 10 to 30 wt% antiadhesive agent to PVA can improve spraying speed.

• Adding talc to PVA can improve PVA's moisture barrier ability.

Granulation Binder

• PVA has good binding and adhesive ability, so it can improve hardness and reduce abrasion of tablets as binder.

• Tablet granulated with PVA shows higher tablet hardness than other tablets.

Anti Capping Effect of PVA

PVA has better adhesive ability than PVP and it can prevent capping.

Solid Dispersion (HME)

PVA is started to be used for HME carrier.

HME Test Conditions

* Machine: Minilab III (Thermo Fisher Scientific Haake)

Dissolution Test