L-HPC (Low-substituted hydroxypropylcellulose)
L-HPC is a low-substituted hydroxypropyl ether of cellulose within a small portion of the hydroxypropyl groups in the glucose unit. Whereas hydroxypropylcellulose (MS*=3) is soluble in both water and alcohol, L-HPC (MS*=0.2-0.4) swells in water and is insoluble.
L-HPC is used as a binder and a disintegrant for solid dosage forms. It was brought onto the market in 1977, and then listed in the JP in 1986, in the NF in 1990 and in the EP in 2016. This product exhibits a wide range of compatibility with many active substances. It is a suitable binder and disintegrant for a formulation study.
We have developed a NBD for the L-HPC family. This is chemically identical to the current L-HPC grades, but particle shape is physically designed to significantly improve binding capability.
MS*: molar substitution.
L-HPC Disintegrant with Binding Properties
(Low-Substituted Hydroxypropyl Cellulose; NF)
LH series
| Grade | Particle appearance | Characteristics | Hydroxypropoxy content(%) | Mean particle size(μm) | 90 % cumulated particle size(μm) | Typical application |
|---|---|---|---|---|---|---|
| LH-11 | Most fibrous | Highly anti-capping effect | 11 | 55 | 175 | Direct compression, Wet granulation (anti-capping) |
| LH-21 | Moderately fibrous | Regular grade | 11 | 45 | 135 | Direct compression, Wet granulation |
| LH-22 | Moderately fibrous | High swelling speed | 8 | 45 | 135 | Direct compression, Wet granulation (sometimes better disintegration) |
| LH-B1 | Non fibrous/High density | Highly swelling force | 11 | 55 | 125 | Fluid-bed granulation, direct compression for high-load formulation |
| LH-31 | Micronized | High binding strength | 11 | 20 | 70 | Pellet extrusion, layering |
| LH-32 | Micronized | High binding strength | 8 | 20 | 70 | Pellet extrusion, layering |
NBD series
| Grade | Particle appearance | Characteristics | Hydroxypropoxy content(%) | Mean particle size(μm) | 90 % cumulated particle size(μm) | Typical application |
|---|---|---|---|---|---|---|
| NBD-022 | Short fiber (uniformly) | High swelling speed | 8 | 45 | 100 | Oral disintegrating tablet, Direct compression |
| NBD-021 | Short fiber (uniformly) | Regular garde | 11 | 45 | 100 | Direct compression, Wet granulation |
| NBD-020 | Short fiber (uniformly) | High binding strength | 14 | 45 | 100 | Wet granulation |