Wet Granulation: High Shear and Fluidized Bed
CELNY can be readily dissolved in both water and most organic solvents to prepare effective granulation solution. Poor flow and compaction actives can be successfully granulated using CELNY to make tableting more feasible through both high shear wet granulation and fluidized bed granulation methods.
Image of granulation using CELNY as bridging polymer
CELNY GRADES
| CELNY | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm |  ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATION | High Shear Granulation  | ||||||
| Fluidized Bed Granulation | |||||||
＊ Particle size of the Regular Powder: 85μm
= Dry / Powder Use
= Wet / Solution Use
Dry Granulation: Direct Compression and Roller Compaction
CELNY is highly plastic and deformable, and exhibits high cohesive and adhesive forces, all important characteristics of a robust direct compression dry binder used for solid oral dosage forms. We often recommend CELNY SSL-SFP for some of the most challenging direct compression formulations because of its super fine particle size, high plasticity and enhanced compressibility, allowing formulators to create tablets of outstanding quality.
CELNY GRADES
| CELNY | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm | ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATION | Direct Compression Dry Granulation
| ||||||
＊ Particle size of the Regular Powder: 85μm
= Dry / Powder Use
Film Coating
CELNY is suitable for both aqueous and organic coating systems. It provides a robust yet flexible film coating with low tackiness, high moisture barrier properties as well as sharper imprint definition. CELNY L, SL and SSL are recommended.
CELNY GRADES
| CELNY | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm | ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATION | Film Coating | ||||||
| Plasticizer for Film Coating | |||||||
Controlled Release
Higher molecular weight/viscosity grades of CELNY can be used for controlled release hydrophilic matrix tablets. Typical addition rate between 20-30% for effective delayed release of active ingredients are possible. CELNY H and VH are recommended.
CELNY GRADES
| CELNY | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm | ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATION | Controlled Release Matrix Tablets | ||||||
- General Information
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Applications
