NISSO HPC
NISSO HPC (Hydroxypropyl Cellulose) is a modified cellulose obtained by reacting propylene oxide with cellulose. The presence of hydroxypropoxy group prevents the hydrogen bonding between the hydroxy groups on the cellulose chain, thereby making HPC soluble.
NISSO HPC was first sold in Japan in 1969 and is globally approved for use in food product and as a pharmaceutical excipient. Nippon Soda has multiple manufacturing lines in Niigata, Japan which have been fully IPEC GMP compliant since 2010.
By Soil-Science.info on Flickr (USDA Natural Resources Conservation Service) - Flickr, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=6076993
By Soil-Science.info on Flickr
(USDA Natural Resources Conservation Service)- Flickr, CC BY 2.0,
https://commons.wikimedia.org/w/index.php?cu-rid=6076993
Features of NISSO HPC
Highest efficiency tablet binder
Soluble in water and polar organic solvents
Nonionic, nonreactive, nontoxic
Eight different molecular weight grades produced designed for immediate or sustained release
Three different particle size grades tailored to wet or dry application
Minimal lot-to-lot variability enabling Quality By Design
Global regulatory approval in food and pharma
5-year shelf life
No additives such as silica
Physical and Chemicals Characteristics
Solution Characteristics
Viscosity vs. Solution Concentration (aq.)
Viscosity vs. Solution Concentration (ethanol)
Viscosity vs Temperature Curve
| Gelation Temperature | SSL-20% | SL-10% | L-8% | M-2% | H-1% | VH-1% |
|---|---|---|---|---|---|---|
| Temp.(℃) | 50 | 47 | 45 | 42 | 41 | 41 |
Thermal Cohesiveness
Moisture content over time
Effect of pH on HPC aqueous viscosity
2% solutions of HPC were measured at various pH at 20°C.
Solubility of HPC-L 2%
| Solution name (general name) | Viscosity (mPa·s) | Viscosity ratio（＊1） | Appearance | Solubility（＊2） |
|---|---|---|---|---|
| Water | 6.3 | 1 | Transparent | ◯ |
| Methanol | 3.4 | 0.5 | Transparent | ○ |
| Ethanol | 6.9 | 1.1 | Transparent | ○ |
| Isopropyl alcohol | 13.1 | 2.1 | Transparent | ○ |
| tert-Butanol | 33.0 | 5.2 | Transparent | △ |
| n-Butanol | 17.0 | 2.7 | Transparent | ○ |
| Cyclo-hexanol | 397.0 | 62.7 | Transparent | △ |
| Propylene glycol | 276.0 | 43.6 | Transparent | △ |
| Acetone | 2.0 | 0.3 | Very slight clouding | △ |
| Cyclohexanone | 16.9 | 2.7 | Transparent | ○ |
| THF | 3.5 | 0.6 | Transparent | ○ |
| Dioxane | 8.5 | 1.3 | Very slight clouding | △ |
| Cellosolve | 12.6 | 2.0 | Transparent | ○ |
| Butyl cellosolve | 19.1 | 3.0 | Transparent | ○ |
| Glacial acetic acid | 9.4 | 1.5 | Transparent | ○ |
| Formic acid | 11.5 | 1.8 | Transparent | ○ |
| Lactic acide | 416.0 | 65.7 | Transparent | △ |
| Ethyl acetate | ― | ― | Dense clouding | × |
| Butyl acetate | ― | ― | Dense clouding | × |
| DMF | 4.7 | 0.7 | Transparent | ○ |
| DMSO | 10.9 | 1.7 | Transparent | ○ |
| Pyridine | 5.8 | 0.9 | Transparent | ○ |
| Methyl chloride | 5.9 | 0.9 | Transparent | ○ |
| Chloroform | 7.7 | 1.2 | Transparent | ○ |
| Benzene:Methanol（1：1） | 3.8 | 0.6 | Transparent | ○ |
| Toluene:Ethanol（3：2） | 4.6 | 0.7 | Transparent | ○ |
| Glycerin:Water（3：7） | 15.3 | 2.4 | Transparent | ○ |
（＊１）Aqueous solution is defined as 1.
（＊２）○=Soluble, △=Difficult to dissolve, ×=Insoluble
- General Information
- NISSO HPC Grades
-
Applications
-
Applications