Orally Disintegrating Tablet (ODT)
Lower molecular weight/viscosity grades of NISSO HPC can be effectively used for fast dissolving ODT formulations. HPC SSL and HPC SSL-SFP are recommended
Orally Disintegrating Film
Lower molecular weight/viscosity grades of NISSO HPC can be effectively used for ODF formulations. HPC SSL is recommended.
Controlled Release
Higher molecular weight/viscosity grades of NISSO HPC can be used for controlled release hydrophilic matrix tablets. Typical addition rate between 20-30% for effective delayed release of active ingredients are possible. HPC H and VH are recommended.
NISSO HPC Grades
| NISSO HPC | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm |  ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATIONS | Controlled Release Matrix Tablets  | ||||||
＊ Particle size of the Regular Powder: 85μm
= Dry / Powder Use
= Wet / Solution Use
Film Coating
NISSO HPC is suitable for both aqueous and organic coating systems. It provides a robust yet flexible film coating with low tackiness, high moisture barrier properties as well as sharper imprint definition. HPC L, SL and SSL are recommended.
NISSO HPC Grades
| NISSO HPC | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm | ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATION | Film Coating | ||||||
| Plasticizer for Film Coating | |||||||
＊ Particle size of the Regular Powder: 85μm
= Dry / Powder Use
= Wet / Solution Use
Solubility Enhancement
Through solubility enhancement methods such as hot melt extrusion, spray drying or nano-suspension, NISSO HPC can act as the stabilizing polymer for the amorphous solid dispersion matrix.
| NISSO HPC | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm | ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATION | hot melt extrusion
| ||||||
| spray drying | |||||||
| nano-suspension | |||||||
＊ Particle size of the Regular Powder: 85μm
= Dry / Powder Use
= Wet / Solution Use
Sterile Filtration
NISSO HPC is suitable for sterile filtration application because of its high purity and lack of additives such as silica. Filtration efficiency depends on the concentration of HPC, its viscosity as well as the filter used. HPC SSL, SL and L are recommended.
| NISSO HPC | SSL | SL | L | M | H | VH | |
|---|---|---|---|---|---|---|---|
| Viscosity (mPa·s) 20℃/2% aq. solution | 2.0-2.9 | 3.0-5.9 | 6.0-10.0 | 150-400 | 1000-4000 | 4001-6000 | |
| Molecular weight / GPC-RI method | 40,000 | 100,000 | 140,000 | 700,000 | 1,000,000 | 2,500,000 | |
| AVAILABILITY | Regular Powder (40 mesh pass) D50: 150-190 μm | ＊ | | | | | |
| Fine Powder (100 mesh pass) D50: 80-110 μm | | | | | | ||
| Super Fine Powder (330 mesh pass) D50: 20 μm | | ||||||
| APPLICATION | Sterile Filtration | ||||||
＊ Particle size of the Regular Powder: 85μm
= Dry / Powder Use
= Wet / Solution Use
- General Information
- NISSO HPC Grades
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Applications
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Applications